Who acts Mrs. Wheeler Wheeler? What actor embodies the role of Karen Wheeler in the show? Who is the performer behind Karen Wheeler? Mrs. Wheeler is portrayed by which actress? Who acts as the character of Karen Wheeler on the series? Who is the talent bringing Karen the mother's character to life? What actress takes on the role of Karen Mrs. Wheeler in the series? Who performs Karen Mrs. Wheeler? Who is the talented individual embodying Karen the mother on the show? What actress embodies the character of Karen Wheeler to the screen?